LEADS

• Adult over 18
• with or without COVID-19
• in intensive care unit,
• mechanical ventilation for more than 48 hours prior to spontaneous breathing trial,
• whether the patient is ready to undergo a spontaneous breathing trial within the next 24 hours with a view to extubation.

1. Suffer from known or suspected peripheral severe myopathy or neuropathy, or limb weakness or paralysis or central (e.g. post arrest, large intracranial stroke or bleed) injury or Glasgow Coman Scale (GCS) < 6

2. Do not wish to be re-intubated as part of their treatment goals

3. Were previously extubated during the same ICU admission

4. Have undergone 1 or more SBTs

5. Already have a tracheostomy

6. Are moribund or expected to die