Active

Studies

This page lists currently active studies at the CHUM ICU.

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DRIVE

What is the optimal ventilation strategy lung protective ventilation, driving pressure-limited ventilation, and lung/diaphragm-protective ventilation and sedation strategies.?

ventilated

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REMAP-CAP (MACROLIDE)

Does one of several investigational therapies improve all-cause mortality in adult patients admitted to the ICU for severe community-acquired pneumonia who are undergoing organ support?

pharmacologic

covid

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REMAP-CAP (CONVALESCENT PLASMA)

Does one of the numerous experimental therapies improve all-cause mortality in adult patients admitted to intensive care for severe community-acquired pneumonia who require organ support?

nonpharmacologic

covid immunosuppression

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REMAP-CAP (ANTIBIOTIC)

Does one of the numerous experimental therapies improve all-cause mortality in adult patients admitted to intensive care for severe community-acquired pneumonia who require organ support?

pharmacologic

infection covid

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LEADS

evaluate the feasibility of using a new decision-making tool, Extubation Advisor (EA), in the ICU to help doctors make decisions about whether a patient in ICU should have their breathing tube removed

ventilation

ventilated

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LANDMARK

which ventilation strategy helps patients the most out of the lung protective ventilation, driving pressure-limited ventilation, and lung/diaphragm-protective ventilation and sedation strategies.

ventilation

ventilated

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Prob-Fluid

Does a protocolized dialysis prescription regimen result in a lower net fluid balance than usual care?

nonpharmacologic

renal

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NOVARTIS (CTIN816B12202)

To determine the safety and efficacy of TIN816 via a single intravenous infusion in the treatment of participants with acute kidney injury associated with sepsis.

pharmacologic

infection renal

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VICTORY

Does high-dose intravenous vitamin C, as compared with placebo, reduce all-cause mortality and persistent organ dysfunction in patients with severe, life-threatening burn injury?

nonpharmacologic

burn-victim

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TRICS IV

Does a restrictive transfusion strategy (Hb < 75 g/L) improve all-cause mortality in patients ≤ 65 years of age undergoing cardiac surgery?

nonpharmacologic

cardiac

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REMAP-CAP (MECHANICAL VENTILATION)

Does one of several investigational therapies improve all-cause mortality in adult patients admitted to the ICU for severe community-acquired pneumonia who are undergoing organ support?

ventilation

covid ventilated

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FISSH

In patients with septic shock, what is the impact of using lower chloride concentration fluids as compared to higher chloride concentration fluids on mortality and acute kidney injury?

nonpharmacologic

infection

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