Does a restrictive transfusion strategy (Hb < 75 g/L) improve all-cause mortality in patients ≤ 65 years of age undergoing cardiac surgery?
Patient Type
Cardiac
INTERVENTION Type
Nonpharmacologic
GROUP A
Liberal (Hb < 95g/L in ICU or Hb < 85g/L on ward)
GROUP B
Restrictive (Hb < 75g/L)
INCLUSION CRITERIA
1. ≥ 18 and ≤ 65 years of age
2. Planned cardiac surgery using cardiopulmonary bypass
3. Informed consent obtained
4. Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of
6 or more
INCLUSION TIME LIMIT
-
EXCLUSION CRITERIA
1. Patients who refuse participation
2. Patients who are unable to receive or who refuse blood products
3. Patients who are involved in a preoperative autologous pre-donation program
4. Patients who are having a heart transplant or having surgery solely for an insertion of a
ventricular assist device
5. Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization
for women of childbearing potential)
Call your research coordinator #20064 - #20065 - #20093
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