Does high-dose intravenous vitamin C, as compared with placebo, reduce all-cause mortality and persistent organ dysfunction in patients with severe, life-threatening burn injury?
Patient Type
Burn victim
INTERVENTION Type
Nonpharmacologic
GROUP A
Placebo
GROUP B
Vitamin C
INCLUSION CRITERIA
1. Age ≥18 years old
2. Deep 2nd and/or 3rd degree burns requiring skin grafting with a minimum of Total Body Surface Area (TBSA) burn ≥ 20%
INCLUSION TIME LIMIT
24 hours following burn injury
EXCLUSION CRITERIA
1. >24 hours from admission to ICU or burn unit to assessment.
2. Patients admitted to burn unit >24 hours from injury or accident.
3. Patients who are moribund (not expected to survive the next 72 hours).
4. Pregnancy (pregnancy will be ruled out as part of standard of care) or lactating.
5. Enrolment in another industry sponsored ICU intervention study
6. Receiving high-dose IV vitamin C already (enteral or oral vitamin C is allowed).
7. Known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
8. Recent history of kidney stones (within the last year).
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